Maria Montiel Gonzalez
Company: Beam Therapeutics
Job title: Scientist, RNA editing platform
Maria Montiel Gonzalez a native from Maracaibo, Venezuela moved to Puerto Rico to pursue her undergraduate studies at the Universidad del Sagrado Corazon. Following this, she obtained her Ph.D. from the Department of Biochemistry of the University of Puerto Rico at the Medical Sciences Campus under the supervision of Dr. Joshua Rosenthal at the Institute of Neurobiology in Old San Juan, Puerto Rico. During her doctorate she published several pioneering studies on site-directed RNA editing using a novel approach to direct the catalytic activity of human ADAR2 to specific adenosines within the RNA. She continued developing this promising therapeutic tool adapting the system for viral delivery at the Marine Biological Laboratory at Woods Hole, Massachusetts. Currently she accepted a position as an R&D Scientist at Beam Therapeutics landing her expertise to the platform of site-directed RNA editing.
Current Strategies for Site-Directed RNA editing using ADARs 9:50 am
• Discuss the different SDRE strategies that have been developed in order to correct G to A genetic mutations and engineer protein function • Difference and comparisons between approaches: • First approach coupling the catalytic domain of ADAR to a guide RNA and a second approach mimicking naturally occurring RNA structures to recruit endogenous ADAR…Read more
day: Day One