Dr. Joshua Rosenthal
Company: Marine Biological Laboratory
Job title: Senior Scientist
Dr. Joshua Rosenthal is a Senior Scientist at the Marine Biological Laboratory in Woods Hole, Massachusetts. He received his B.S. in biology from Haverford College. He completed his doctoral work at Stanford University under the supervision of William Gilly, focusing on the voltage-dependent ion channels expressed in the squid giant axon. As a postdoc at UCLA with Francisco Bezanilla he studied RNA editing in the messages that encode the squid ion channels and how they affected function. Before moving to the Marine Biological Laboratory, he rose from Assistant Professor to Professor at the Institute of Neurobiology in San Juan, Puerto Rico. Dr. Rosenthal’s lab has long focused on high-level RNA editing in cephalopods. These studies inspired his group to pioneer strategies to use RNA editing by adenosine deamination as a therapeutic. He is an academic founder of Korro Bio and continues to develop new strategies for site-directed RNA editing.
Directed RNA Editing, How it has Evolved and General Applications 8:40 am
• Limitations of the systems and how to get beyond these • New enzymatic functions and how to discover more • If we can determine C-U editing, we can double the applications • Considerations of longevity of response to tailor for transient and temporary conditions (setting ourselves apart from CRISPR cas 9) • Speculation about…Read more
day: Day One