Dong Wei

Dong Wei

Company: Edigene

Job title: Chief Executive Officer


LEAPER: A Novel Oligonucleotide-Based RNA Base Editing Therapy Delivered via Lipid Nanoparticles (LNP) or Adenoassociated Virus (AAV) 9:30 am

• LEAPER (Leveraging endogenous ADAR for programmable editing of RNA) enables precise and sequence specific A-to-I conversion at a desired mRNA sequence • Synthetic LEAPER-based oligonucleotides (arRNA) delivered through LNP generated robust editing efficiency in vitro and in IDUA W392X mouse model, a model of MPS I disease • arRNA expressed by AAV generated robust…Read more

day: Day Two

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