How ADAR1 can drive Disease Progression by Acting Both as an RNA Editor of Specific Transcripts & as a DNA Mutator of their Cognate Genes

Time: 1:00 pm
day: Day Two

Details:

• Evaluating RNA editing vs DNA mutation in cancer
• (Some) deaminases can act as RNA editors and DNA mutators
• Exploiting dual function enzymes for therapeutic purposes

Speakers:

Nina Papavasiliou
Nina Papavasiliou

I have a long-standing interest in processes that generate informational diversity within cells. This interest originally directed my lab’s work to DNA mutation in the context of the adaptive immune response specifically to mechanisms that direct mutation to antibody genes in the germinal center. This process which depends on AID-mediated DNA deamination followed by error…Read more